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Antibiotic Basics for Clinicians: The ABCs of Choosing the by Alan R. Hauser MD PhD PDF

By Alan R. Hauser MD PhD

ISBN-10: 1451112211

ISBN-13: 9781451112214

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Extra resources for Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent Second Edition

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Mascaretti OA. Bacteria versus Antibacterial Agents: An Integrated Approach. Washington, DC: ASM Press; 2003. Thompson RL, Wright AJ. Symposium on antimicrobial agents, parts I–XVII. Mayo Clin Proc. 1998–2000:73–75. Walsh C. Antibiotics: Actions, Origins, Resistance. Washington, DC: ASM Press; 2003. indd 16 12/15/11 2:23 AM CHAPTER 5 Antibiotics that Target the Cell Envelope “Though the knights, secure in their heavy armour, had no scruples in riding down and killing the leather-clad foot-soldier, it is entertaining to read of the fierce outcry they made when the foot-soldier retaliated with steel crossbow.

Difficile) Some Bacteroides spp. 12/15/11 2:23 AM 28 Antibiotic Basics for Clinicians Extended-Spectrum Penicillin ϩ ␤-Lactamase Inhibitor Combinations Table 5-8 Antimicrobial Activity of ExtendedSpectrum Penicillin ؉ ␤-Lactamase Inhibitor Combinations Gram-positive bacteria Some Staphylococcus aureus Streptococcus pyogenes Viridans streptococci Some Streptococcus pneumoniae Some enterococci Listeria monocytogenes Gram-negative bacteria Neisseria spp. Haemophilus influenzae Most Enterobacteriaceae Pseudomonas aeruginosa Anaerobic bacteria Clostridia spp.

Indd 19 12/15/11 2:23 AM 20 Antibiotic Basics for Clinicians NAMA NAGA NAMA NAMA G NAMA NAGA GG GG NAGA GG GG G β-lactam PBP A. Alanine-alanine peptide bond B. NH C β-lactam ring C C C N O O PBP PBP FIGURE 5-3. Mechanism of penicillin-binding protein (PBP) inhibition by ␤-lactam antibiotics. A. PBPs recognize and catalyze the peptide bond between two alanine subunits of the peptidoglycan peptide side chain. B. The ␤-lactam ring mimics this peptide bond. Thus, the PBPs attempt to catalyze the ␤-lactam ring, resulting in inactivation of the PBPs.

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Antibiotic Basics for Clinicians: The ABCs of Choosing the Right Antibacterial Agent Second Edition by Alan R. Hauser MD PhD


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