By Herbert E. Spiegel
This quantity, edited for the final time by means of H.E. Spiegel, maintains the target of increasing the highbrow horizon of medical chemistry. The fields of analytical, anatomical, sub-cellular and molecular sciences are all represented during this quantity. * designated studies by way of training scientists * Covers a wide diversity of medical chemistry on a theoretical and useful foundation * comprises effortless to learn chapters combining technological know-how and views in a altering clinical panorama
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Additional resources for Advances in Clinical Chemistry, Vol. 37
Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody. J. Clin. Invest. 99, 178–184 (1997). H9. Hendrzak, J. , and Brunda, M. , Interleukin-12. Biologic activity, therapeutic utility, and role in disease. Lab. Invest. 72, 619–637 (1995). H10. , p38 MAPK signalling cascades in inﬂammatory disease. Mol. Med. Today 5, 439–447 (1999). H11. , Granulocytemacrophage colony-stimulating factor and IL-5 activate mitogen-activated protein kinase through Jak2 kinase and phosphatidylinositol 3-kinase in human eosinophils.
32 WONG AND LAM 5. Conclusions Cytokine research is a rapidly expanding ﬁeld of immunology, cell biology, and allergy research. The explosion of knowledge in the immunobiology of cytokines can help us to identify novel cytokines, evaluate the detailed roles of cytokines in the pathogenesis of many diseases, and elucidate the detailed intracellular signal transduction mechanisms of different cytokines. The results of these studies will provide a solid biochemical basis for designing new therapeutic approaches for many immunological disorders and for developing new predictive parameters and diagnostic markers for monitoring disease severity and therapeutic efﬁcacies.
Epithelial cells are a major cellular source of the chemokine eotaxin in the guinea pig lung. Allergy Asthma. Proc. 19, 15–22 (1998). Cook, E. , Stahl, J. , Graziano, F. , and Barney, N. , Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based ﬂow cytometry: Allergics vs. non-allergics. J. Immunol. Meth. 254, 109–118 (2001). , Doza, Y. , Gallagher, T. , Young, P. , and Lee, J. , SB 203580 is a speciﬁc inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1.
Advances in Clinical Chemistry, Vol. 37 by Herbert E. Spiegel
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