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A calcium-based phantom bursting model for pancreatic islets by Richard Bertram, Arthur Sherman PDF

By Richard Bertram, Arthur Sherman

Insulin-secreting β-cells, situated in the pancreatic islets of Langerhans, are excitable cells that produce commonplace bursts of motion potentials whilst influenced by means of glucose. the program has been the point of interest of mathematical research for 2 many years, spawning an array of mathematical types. lately, a brand new type of versions has been brought known as 'phantom bursters' [Bertram et al. (2000) Biophys. J. seventy nine, 2880-2892], which bills for the wide variety of burst frequencies exhibited via islets through the interplay of multiple sluggish procedure. the following, we describe one implementation of the phantom bursting mechanism during which intracellular Ca2+ controls the oscillations via either direct and oblique detrimental suggestions pathways. We exhibit how the version dynamics could be understood via an extension of the fast/slow research that's ordinarily hired for bursting oscillations. From this attitude, the version uses a number of levels of freedom to generate the complete variety of bursting oscillations exhibited through β-cells. The version additionally debts for quite a lot of experimental phenomena, together with the ever-present triphasic reaction to the step elevation of glucose and responses to perturbations of inner Ca2+ shops. even though it isn't really almost immediately an entire version of all β-cell houses, it demonstrates the layout ideas that we expect will underlie destiny development in β-cell modeling.

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A. Tengholm, E. Grapengiesser, B. Hellman and E. Gylfe (1998). Origin of slow and fast oscillations of Ca2+ in mouse pancreatic islets. J. Physiol. ) 508, 471–481. Longo, E. , K. Tornheim, J. T. Deeney, B. A. Varnum, D. Tillotson, M. Prentki and B. E. Corkey (1991). Oscillations in cytosolic free Ca2+ , oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J. Biol. Chem. 266, 9314–9319. Magnus, G. and J. Keizer (1997). Minimal model of β-cell mitochondrial Ca2+ handling.

F. III, M. S. McIntyre, B. Spencer, R. J. Mertz, M. W. Roe and I. D. Dukes (1994). Endoplasmic reticulum calcium store regulates membrane potential in mouse islet β-cells. J. Biol. Chem. 269, 14359–14362. , P. Goforth, R. Bertram, A. Sherman and L. Satin (2003). The Ca2+ dynamics of isolated mouse β-cells and islets: implications for mathematical models. Biophys. J. 84, 2852–2870.

Grapengiesser, B. Hellman and E. Gylfe (1998). Origin of slow and fast oscillations of Ca2+ in mouse pancreatic islets. J. Physiol. ) 508, 471–481. Longo, E. , K. Tornheim, J. T. Deeney, B. A. Varnum, D. Tillotson, M. Prentki and B. E. Corkey (1991). Oscillations in cytosolic free Ca2+ , oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J. Biol. Chem. 266, 9314–9319. Magnus, G. and J. Keizer (1997). Minimal model of β-cell mitochondrial Ca2+ handling. Am. J.

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A calcium-based phantom bursting model for pancreatic islets by Richard Bertram, Arthur Sherman


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